^ Robison AJ, Nestler EJ (October 2011). "Transcriptional and epigenetic mechanisms of addiction". Nature Reviews. Neuroscience. 12 (11): 623–37. doi:10.1038/nrn3111. PMC 3272277. PMID 21989194. ΔFosB has been linked directly to several addiction-related behaviors ... Importantly, genetic or viral overexpression of ΔJunD, a dominant negative mutant of JunD which antagonizes ΔFosB- and other AP-1-mediated transcriptional activity, in the NAc or OFC blocks these key effects of drug exposure14,22–24. This indicates that ΔFosB is both necessary and sufficient for many of the changes wrought in the brain by chronic drug exposure. ΔFosB is also induced in D1-type NAc MSNs by chronic consumption of several natural rewards, including sucrose, high fat food, sex, wheel running, where it promotes that consumption14,26–30. This implicates ΔFosB in the regulation of natural rewards under normal conditions and perhaps during pathological addictive-like states.
As a person’s drug abuse turns into addiction, they will develop an increased tolerance to the drug, requiring larger doses of it in order to achieve the desired “high.” If addiction is left untreated, the end result is always devastation and loss on every level; the further along in the disease of addiction a person gets, the harder it will be for them to recover. Thus, treating drug addiction as soon as possible is always the best option.
Research the history of the Treatment Center or facility. What is their success rate? Can you find any medical recommendations for them online from members of the established rehab or medical community? How long has the Center been in operation? Is their leadership on solid ground? Are there any signs of financial corruption associated with the Center that is readily visible on the Internet? It is your responsibility to dig for this information. If you cannot find any information about a given Treatment Center online or at your local library, move on to the next Center on your list! 3 Stages of Drug Alcohol Rehab-How It Works