One study tracked the weekly drug use among individuals who attended residential treatment centers. After one year post discharge they discovered that there is a correlation between retention rates and the length of stay at a facility. Individuals coming form programs of 90 days or more showed a lower relapse rate than those coming from programs of less than 90 days. Drug Addiction : How to Help Someone with a Meth Addiction
Withdrawal can begin soon after the cessation of drug use and will likely peak in intensity in the first 24 to 48 hours. If severe withdrawal is left unchecked, in some instances it can be fatal. Anyone experiencing the symptoms of withdrawal should be under a doctor’s care, and for drug addicts entering treatment medical detox is often required before therapy for addiction can begin.
Most drugs affect the brain's "reward circuit," causing euphoria as well as flooding it with the chemical messenger dopamine. A properly functioning reward system motivates a person to repeat behaviors needed to thrive, such as eating and spending time with loved ones. Surges of dopamine in the reward circuit cause the reinforcement of pleasurable but unhealthy behaviors like taking drugs, leading people to repeat the behavior again and again.
^ Robison AJ, Nestler EJ (October 2011). "Transcriptional and epigenetic mechanisms of addiction". Nature Reviews. Neuroscience. 12 (11): 623–37. doi:10.1038/nrn3111. PMC 3272277. PMID 21989194. ΔFosB has been linked directly to several addiction-related behaviors ... Importantly, genetic or viral overexpression of ΔJunD, a dominant negative mutant of JunD which antagonizes ΔFosB- and other AP-1-mediated transcriptional activity, in the NAc or OFC blocks these key effects of drug exposure14,22–24. This indicates that ΔFosB is both necessary and sufficient for many of the changes wrought in the brain by chronic drug exposure. ΔFosB is also induced in D1-type NAc MSNs by chronic consumption of several natural rewards, including sucrose, high fat food, sex, wheel running, where it promotes that consumption14,26–30. This implicates ΔFosB in the regulation of natural rewards under normal conditions and perhaps during pathological addictive-like states.

Getting alcohol out of the addicted person’s system is the first part of recovery. People with a severe alcohol addiction can experience intense withdrawal symptoms. A supervised alcohol detox is usually necessary for people addicted to alcohol to prevent potentially fatal complications. Shaking, sweating, seizures, and hallucinations are possible alcohol withdrawal symptoms. Woman Turns to Rehab After Struggling With Drugs, Alcohol: Part 1
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